Cell surface topography and diffusion in the plasma membrane

Cells are neither smooth nor flat and we have demonstrated that ignoring cell surface topography results in an overestimation of anomalous diffusion in the plasma membrane. To complement our simulations and fluorescence correlation spectroscopy studies, we collaborate with the group led by Patrick Happel to obtain high resolution topography maps of live cells using ion conductance microscopy.

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  • Adler J et al.: Plasma membrane topography and interpretation of single-particle tracks. Nat Methods 2010 DOI: 10.1038/nmeth0310-170
  • Parmryd I & Önfelt B: Consequences of membrane topography. FEBS J 2013 DOI: 10.1111/febs.12209
  • Adler J et al.: Conventional analysis of movement on non-flat surfaces like the plasma membrane makes Brownian motion appear anomalous. Commun Biol 2019 DOI: 10.1038/s42003-018-0240-2
  • Gesper A et al.: Variations in Plasma Membrane Topography Can Explain Heterogenous Diffusion Coefficients Obtained by Fluorescence Correlation Spectroscopy. Front. Cell Dev. Biol. 2020 DOI: 10.3389/fcell.2020.00767


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