Proteomic response of bacteria

We use pulse-labeling to investigate the proteins newly synthesized in response to stress, e.g. antibiotic treatment.

Funded by

  • BMBF (16GW0225): Natural product-nanocarrier conjugates, a novel dual-mode strategy to combat resistant bacteria (NanoComBac)
  • Deutsche Forschungsgemeinschaft (BA 4193/6-1): Die Rolle von Calcimycin im Kampf um Eisen
  • National Institutes of Health (R01GM121650): Physiology of ribosome rescue in bacteria
  • EFRE, Investing in your future, NRW (EFRE-0200597): Center for system-based antibiotic research (CESAR), VISA
  • DAAD (57389759): Investigating mechanism of action of membrane targeting antibacterial agents


  • Senges CHR et al.: Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrob Agents Chemother 2021 DOI: 10.1128/AAC.01373-20
  • Schäkermann S et al.: Applicability of Chromatographic Co‐Elution for Antibiotic Target Identification. Proteomics 2020 DOI: 10.1002/pmic.202000038
  • Meier D et al.: The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria. Bioorganic & Medicinal Chemistry 2019 DOI: 10.1016/j.bmc.2019.115151
  • Wüllner D et al.: Interspecies Comparison of the Bacterial Response to Allicin Reveals Species‐Specific Defense Strategies. Proteomics 2019 DOI: 10.1002/pmic.201900064


  • Lea Schipp: Biologische Charakterisierung von Fettsäurebiosynthese- und Zellwandbiosyntheseinhibitoren (Bachelor's thesis, 2021)
  • Mona Otte: Vergleich der Reaktion von Bacillus subtilis auf die Hemmung der trans-Translation und die Behandlung mit Kupfer und Wasserstoffperoxid (Bachelor's thesis, 2020)
  • Carla Barrie: Proteomanalyse zur Untersuchung des synergistischen Effektes von Kupfer und trans-Translations Inhibitoren in E. coli (Bachelor's thesis, 2019)
  • Cindy Juric: Effects of ribosome rescue inhibitors on the physiology of Escherichia coli. (Master's thesis, 2020)
  • Ümran Ay: Analyse der Wirkmechanismen Thiol-aktiver Antibiotika (Master's thesis, 2018)