This project is closed.

Funtionalized Nanodiamonds for Biomedical Research and Therapy

Nanodiamonds are biocompatible nanoparticles, which can be functionalized by manifold surface modifications. Therefore, they are an excellent candidate for biomedical and even therapeutic applications. Here we aim at developing nanodiamonds labeled by different lattice modifications, such that they are detectable by various techniques, from microscopy and radiography to magnet resonance imaging. Modifying the nanodiamond lattice instead of its surface ensures that the nanoparticle and its label do not dissolve in physiologic environment. Additionally, it does not alter its interactions with the environment and hence the biocompatibility of the nanoparticle is preserved. A nanoparticle that is not detectable due to surface but to lattice modifications for the first time allows comparable investigations from the subcellular to organism level, eventually leading to the development of nanodiamond based tools for biomedical and therapeutic applications.

Funded by

  • VolkswagenStiftung (88390): Functionalized Nanodiamonds for Biomedical Research and Therapy

Publications

  • Gesper A et al.: A low-cost, large field-of-view scanning ion conductance microscope for studying nanoparticle–cell membrane interactions. Nanoscale 2017 DOI: 10.1039/C7NR04306F
  • Hagemann P et al.: Correlative Stimulated Emission Depletion and Scanning Ion Conductance Microscopy. ACS Nano 2018 DOI: 10.1021/acsnano.8b01731
  • Happel P et al.: Intrinsically 32P-Labeled Diamond Nanoparticles for In Vivo Imaging and Quantification of Their Biodistribution in Chicken Embryos. Adv. Funct. Mater. 2018 DOI: 10.1002/adfm.201802873
  • Heesch D et al.: Implantation of defined activities of phosphorus 32 with reduced target damage. Review of Scientific Instruments 2018 DOI: 10.1063/1.5019014

Theses

This project has no theses.